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Bader Lab

Computational Network Biology

We study the organization and evolution of biological systems using computational biology and bioinformatics techniques. We seek to accurately predict links, such as specific molecular interactions, in eukaryotic cell signaling systems using comprehensive genomics data like genome sequence and transcript profiles. We are interested to find how these links are rewired by mutations to cause disease. This work is supported through the development of open-source biological pathway and network databases and visualization and analysis software.

Predicting biologically relevant protein interactions
Cellular network evolution
Detection of cell type and stage active biological processes using molecular profiles
Biological pathway and network databases and analysis tools

[:ResearchNonExpert:Non-expert explanation]

Affiliations:BR [http://tdccbr.med.utoronto.ca Terrence Donnelly Centre for Cellular and Biomolecular Research]BR [http://www.utoronto.ca/bandb/ Banting and Best Deparment of Medical Research]BR [http://www.mshri.on.ca/ Samuel Lunenfeld Research Institute] at [http://www.mtsinai.on.ca/ Mount Sinai Hospital]BR [http://www.utoronto.ca/medicalgenetics/ Department of Medical Genetics & Microbiology and the Graduate Department of Molecular and Medical Genetics] a.k.a MedGenBR all associated with the [http://www.utoronto.ca/ University of Toronto]

Where we are:BR160 College Street, Room 602BRTerrence Donnelly Centre for Cellular and Biomolecular ResearchBRUniversity of TorontoBRToronto, OntarioBRCanada, M5S 3E1BR BR[http://maps.google.com/maps?f=q&hl=en&q=160+College+St,+Toronto+ON&om=1 Map] [http://www.news.utoronto.ca/photogalleries/ccbr/slideshow1.htm Pictures] ["TDCCBR 6th Floor"]

Contact:BRGary BaderBRPhone: 416-978-3935BRFax: 416-978-8287BRgary.bader *a-t* utoronto.caBRAlso available by Skype (preferred), iChat, AIM

[http://www.plos.org Support Open Access Publishing]

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-[http://www.utoronto.ca/medicalgenetics/ Department of Molecular Genetics & Microbiology and the Graduate Department of Molecular and Medical Genetics] a.k.a !MedGen[[BR]]
+[http://www.utoronto.ca/medicalgenetics/ Department of Medical Genetics & Microbiology and the Graduate Department of Molecular and Medical Genetics] a.k.a !MedGen[[BR]]