Neurobiological Gene-sets

Phenotypes and Expression Specificity

• '''ExpHsBr: Human Specific Brain Expression'''

• '''PhMmAll: Mouse Neurological Phenotype converted to Human'''

• '''PhHsPsy: Human Neuropsychiatric'''

• '''PhHsDev: Human Neurodevelopmental and Intellectual Disability'''

• '''PhHsMsc: Human Other Neurological'''

Details

• ID: human Entrez-Gene
• [[|Documentation]]
• Notes on use
  • All gene-sets have good quality with respect to enrichment in neuropsychological functions and phenotypes

  • ExpHsBr and PhMmAll are the ones I found of higher quality when overlapping with my autism gene-set analysis results

  • PhHsPsy probably includes several genes from candidate gene studies, but is otherwise of good quality

  • The distinction between PhHsPsy and PhHsDev is a bit loose, these two gene-sets could be collapsed

  • PhMmAll is not completely unbiased, as investigators will make KO mouse models for genes of interest

  • ExpHsBr may be partially biased towards well characterized genes

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