#acl All:read ##master-page:HomepageTemplate #format wiki {{attachment:Members/binnes.jpg}} == Brendan Innes == Email: <> I am a PhD candidate in Molecular Genetics who started in the Bader lab in May, 2016. I am very excited about the possibilities offered by high-throughput single-cell RNA-seq, especially to investigate intercellular signalling in complex tissues. === High-thoughput single-cell RNAseq analysis pipeline === I've built a simple pipeline and visualization tool to help collaborators go from raw gene expression counts per cell to exploring annotated cell-type specific gene expression data in a quick and reproducible way. Below is a quick video of a prototype of the visualization tool in action, showing the sort of data one can get from this pipeline. If you're interested in applying the pipeline to your count-based single-cell data, please get in touch! {{attachment:scRNAseqViz.mp4||height=543, width=800}} === Education === MSc in Biochemistry at the University of Western Ontario, supervised by [[https://www.schulich.uwo.ca/biochem/people/bios/Litchfield.html|Dr. David Litchfield]] BMSc in Cell Biology and Biochemistry at the University of Western Ontario === Teaching Experience === TA for MBP1010H - Quantitative Biology and Statistical Methods === Publications === Yuzwa SA, Borrett MJ, '''Innes BT''', Voronova A, Ketela T, Kaplan DR, Bader GD, Miller FD. Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling. Cell Rep. 21(13):3970-86, 2017. [[http://www.sciencedirect.com/science/article/pii/S2211124717318132]] '''Innes BT''', Sowole MA, Gyenis L, Dubinsky M, Konermann L, Brandl CJ, Litchfield DW, Shilton BH. Peroxide-Mediated Oxidation and Inhibition of the Peptidyl-Prolyl Isomerase Pin1. Biochim Biophys Acta. 1852(5):905-12, 2015. [[http://www.sciencedirect.com/science/article/pii/S0925443915000149|doi:10.1016/jbbadis.2014.12.025]] Sowole MA, '''Innes BT''', Amunugama M, Brandl CJ, Shilton BH, Litchfield DW, Konermann L. Noncovalent binding of a cyclic peptide inhibitor to the peptidyl-prolyl isomerase Pin1 explored by hydrogen exchange mass spectrometry. Can J Chem. July 2014. [[http://www.nrcresearchpress.com/doi/abs/10.1139/cjc-2014-0230|doi:10.1139/cjc-2014-0230]] '''Innes BT''', Bailey ML, Brandl CJ, Shilton BH, Litchfield DW. Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding. Front. Physiol. 4:18, 2013. [[http://journal.frontiersin.org/article/10.3389/fphys.2013.00018/full|doi:10.3389/fphys.2013.00018]] ---- CategoryHomepage