#acl All:read DanieleMerico:write,delete,revert
= Neurobiological Gene-sets =
== Phenotypes and Expression Specificity ==
'''Last update: May 2011'''<<BR>>
Text files
 * [[attachment:Neuro_ExpHsBr.txt|ExpHsBr: Human Brain-Specific Expression]]
 * [[attachment:Neuro_PhMmAll.txt|PhMmAll: Mouse Neurological Phenotypes converted to Human]]
 * [[attachment:Neuro_PhHsPsy.txt|PhHsPsy: Human Neuropsychiatric Disorders]]
 * [[attachment:Neuro_PhHsDev.txt|PhHsDev: Human Neurodevelopmental Disorders and Intellectual Disability]]
 * [[attachment:Neuro_PhHsMsc.txt|PhHsMsc: Human Other Neurological Disorders]]
R Workspace
 * [[attachment:coreNeuroLists.RData|Phenotypes and Expression Specificity gene-sets Rws]]

'''Details'''
 * __ID System__: human Entrez-Gene
 * __Documentation__
   * [[attachment:Documentation_v01.pdf|PDF]]
   * [[attachment:Documentation_v01.pptx|pptx]]
 * __Notes on use__
   * All gene-sets have good quality with respect to enrichment in neuropsychological functions and phenotypes
   * ''!ExpHsBr'' and ''!PhMmAll'' are the ones I found of higher quality when overlapping with my autism gene-set analysis results
   * ''!PhHsPsy'' probably includes several genes from candidate gene studies, but is otherwise of good quality
   * The distinction between ''!PhHsPsy'' and ''!PhHsDev'' is a bit loose, these two gene-sets could be collapsed
   * ''!PhHsMsc'' is quite heterogeneous, and its neurovascular and neurodegenerative auto-immune components are probably source of bad candidates for researchers working on autism, schizophrenia or ADHD
   * ''!PhMmAll'' is not completely unbiased, as investigators will make KO mouse models for genes of interest
   * ''!ExpHsBr'' may be partially biased towards well characterized genes 

== From Gene Ontology ==
'''Last update: April 2011'''<<BR>>
Text files
 * [[attachment:GO_neuro_dev.txt|Human Nervous System Development (GO:0007399)]]
 * [[attachment:GO_neuro_process.txt|Human Nervous System Process (without sensory receptors)]]
   * Cognition (GO:0050890), Neuronal action potential propagation (GO:0019227), Transmission of nerve impulse (GO:0019226)