##master-page:HomepageTemplate #format wiki #acl All:read == Shirley Hui == Shirley is a Research Associate in the Bader Lab at the University of Toronto. '''Email''': <> '''Supervisor''': Gary Bader == Research Projects == * Current * RCC single cell genomics project * [[/RCCscRNAProject/Weekly|Weekly Update]] ## *Breast Cancer GSEA Projects ## * Progess [[http://baderlab.org/ShirleyHui/BreastCancerGSEAProjects|Log]] * Past * Breast Cancer Pathway GSEA Project * [[attachment:BreastCancerPathwayGSEA-2017.pdf|PDF]] * Precision Medicine Projects * [[/../MedicalDecisionMakingProject/Log| Progress Log]] * [[/../DomainSpecificityPredictionProject|PDZ domain interaction prediction]] * Thesis: [[http://hdl.handle.net/1807/43599|Computational Prediction of PDZ mediated Protein-Protein Interactions]] * Supervisory Committee: [[http://www.utoronto.ca/boonelab/|Charlie Boone]], [[http://morrislab.med.utoronto.ca/|Quaid Morris]], [[http://pawsonlab.mshri.on.ca/|Tony Pawson]] * POW! Website: http://webservice.baderlab.org/domains/POW/ ## * [wiki:/../DomainSpecificityPredictionProject/Log Progress] ##== Current Interests == ## * Algorithms: Machine Learning - Support Vector Machines ## * Peptide Recognition Domains: PDZ Domain == Education == * 2007 - 2013 [[http://www.utoronto.ca|University of Toronto]] - Ph.D. Department of Molecular Genetics * 2002 - 2005 [[http://www.cs.uwaterloo.ca/|University of Waterloo]] - M.Math, focus on Computational Biology * 1996 - 2001 [[http://www.cs.uwaterloo.ca/|University of Waterloo]] - B.Math, Honours Computer Science Co-op == Publications == * Association analysis identifies 65 new breast cancer risk loci, Michailidou K, Lindström S, Dennis J, Beesley J, '''Hui S''', et al.<
> [[https://www.nature.com/articles/nature24284|Nature (2017) Nov 2;551(7678):92-94. Epub 2017 Oct 23]] * Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer, Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, '''Hui S''', et al.<
> [[https://www.nature.com/articles/ng.3785|Nat Genet. (2017) Dec;49(12):1767-1778. Epub 2017 Oct 23]] * Predicting PDZ domain mediated protein interactions from structure, '''Hui S''', Xing X, Bader GD<
>[[http://www.biomedcentral.com/1471-2105/14/27/abstract|BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-27]] [[http://www.ncbi.nlm.nih.gov/pubmed/23336252|PubMed Abstract]] [[attachment:pdz-struct-2013.pdf|PDF]] * Domain-mediated protein interaction prediction: From genome to network, Reimand J, '''Hui S''', Jain S, Law B, Bader GD<
> [[http://www.sciencedirect.com/science/article/pii/S001457931200316X|FEBS Lett. 2012 May 3]][[http://www.ncbi.nlm.nih.gov/pubmed/22561014|PubMed Abstract]] [[attachment:Genome2NetworkReview.pdf|PDF]] * Proteome scanning to predict PDZ domain interactions using support vector machines, '''Hui S''', Bader GD<
> [[http://www.biomedcentral.com/1471-2105/11/507|BMC Bioinformatics. 2010 Oct 12;11(1):50]] [[http://www.ncbi.nlm.nih.gov/pubmed/20939902|PubMed Abstract]] [[attachment:2010_HuiBader-ProteomeScanningPDZ_BMCBioinformatics.pdf|PDF]] * Rapid evolution of functional complexity in a domain family, Ernst A, Sazinsky SL, '''Hui S''', Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS<
> [[http://stke.sciencemag.org/cgi/content/full/sigtrans;2/87/ra50|Science Signaling 2009 Sep 8;2(87):ra50]] [[http://www.ncbi.nlm.nih.gov/pubmed/19738200|PubMed Abstract]] [[attachment:2009_Ernst_PDZEvolution_ScienceSignaling_Sep.pdf|PDF]] == Work == * 2006 * Toronto (Sunnybrook Hospital - Medical Imaging) - Research Analyst * 2001 - 2006 * Waterloo (AGFA Healthcare) - Software Development * 1996 - 2001 (Co-op work terms - Software Development) * Ottawa (Corel) * Mississauga (Pervasive Software, Platform Computing) * San fransisco (Evolve Digital Consulting) ## == Skills == ## * Technical: ## * Programming Languages: Java ## * Numerical Analysis Software: Matlab, R ## * Non-Technical: ## * Piano/Read Music (Gr 10 [[http://www.rcmusic.ca/html|Toronto Royal Conservatory]]) ## == Things I Support == ## * [[http://convio.cancer.ca/site/PageServer?pagename=RFL_ON_about_relay|Canadian Cancer Society Relay For Life - Team Steven Hui]] ## * [[http://www.ottawanrf.com/2007/our_kids.htm|Ottawa Neuroblastoma Fund]] ## * [[http://www.earthhour.org/|Earth Hour]] ## * [[http://wwfcentral.ca/NetCommunity/Page.aspx?pid=503&srcid=500|WWF CN Tower Climb]] ## * [[http://www.canadarunningseries.com/sportinglife/|Sporting Life 10K - Easiest 10K!]] ## == Places I Have Worked == ---- CategoryHomepage