Signing of Regulatory Networks (SIREN)
Discrimination of Interaction Type in Biological Networks
The Signing of Regulatory Networks (SIREN) algorithm can infer the regulatory type (positive or negative regulation) of interactions in a known gene regulatory network given corresponding genome-wide gene expression data.
SIREN is an efficient algorithm with low computational complexity; hence, it is applicable to large biological networks. It is a complementary approach for a wide range of network reconstruction methods that do not provide information about the interaction type.